I was wondering if it is possible to use the call routing tables in an Axxess system to route calls on both DNIS and the ANI received on a call. This on a T1 not PRI. My thinking is the first table sorts based on the DNIS and some of those DNIS point to another table with the call routing key changed to outside number. This table would ignore the DNIS and look at the ANI and route calls based on area code. In theory this should work but has anyone done it?

Yes, you can cascade routing tables to accomplish exactly what you described.