You can go straight, only the BCM50 will an R1 need to first go to an R2 or R3 before it goes to R6.

After the upgrade and all seems well do the R6 Image patch as well in case you ever need to do a level reset which will keep it at R6 instead of reverting back to R1.

Make sure to also do the latest patches.

Read this too:
BCM50/450 Upgrade





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